Washington: A team of researchers has used a computer programme to screen a drug library for candidates that could inhibit the coronavirus from replicating. “The COVID-19 virus is a challenge because it continues to evolve,” said lead researcher Bin Chen, College of Human Medicine, Michigan State University. “By using artificial intelligence and really large data sets, we can repurpose old drugs for new uses.”
Chen built an international team of researchers with expertise on topics ranging from biology to computer science to tackle this challenge.
First, Chen and his team turned to publicly available databases to mine for the unique coronavirus gene expression signatures from 1,700 host profiles that came from patient tissues, cell cultures and mouse models.
These signatures revealed the biology shared by COVID-19 and its variants.
With the virus’s signature and knowing which genes need to be suppressed and which genes need to be activated, the team was able to use a computer programme to screen a drug library consisting of FDA-approved or investigational drugs to find candidates that could correct the expression of signature genes and further inhibit the coronavirus from replicating.
Chen and his team discovered one novel candidate, IMD-0354, a drug that passed phase I clinical trials for the treatment of atopic dermatitis.
A group in Korea later observed that it was 90-fold more effective against six COVID-19 variants than Remdesivir, the first drug approved to treat COVID-19.
The team further found that IMD-0354 inhibited the virus from copying itself by boosting the immune response pathways in the host cells.
Based on the information learned, the researchers studied a prodrug of IMD-0354 called IMD-1041.
A prodrug is an inactive substance that is metabolised within the body to create an active drug.
“IMD-1041 is even more promising as it is orally available and has been investigated for chronic obstructive pulmonary disease, a group of lung diseases that block airflow and make it difficult to breathe.
“Because the structure of IMD-1041 is undisclosed, we are developing a new artificial intelligence platform to design novel compounds that hopefully could be tested and evaluated in more advanced animal models,” Chen said.
The research was published in the journal iScience.
This project was led by two senior postdoctoral scholars in the Chen lab: Jing Xing, who recently became a young investigator at the Chinese Academy of Sciences, and Rama Shankar, with the support from researchers from Institut Pasteur Korea, Shanghai Institute of Materia Medica, University of Texas Medical Branch, Spectrum Health in Grand Rapids and Stanford University.